Enhanced Sensitivity to Ethanol-Induced Inhibition of LTP in CA1 Pyramidal Neurons of Socially Isolated C57BL/6J Mice: Role of Neurosteroids

    January 2011 in “ Frontiers in Endocrinology ”
    Giuseppe Talani, Giovanni Biggio, Enrico Sanna
    Studysummary The study found that social isolation in mice increases the sensitivity of their hippocampal synapses to ethanol's inhibitory effects on long-term potentiation, an effect preventable by finasteride.
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    Research cited in this study 6

    1. Changes in Expression and Function of Extrasynaptic GABA A Receptors in the Rat Hippocampus During Pregnancy and After Delivery Journal of Neuroscience · 2009
    2. GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices European Journal of Neuroscience · 2007
    3. Social Isolation-Induced Increase in Alpha-4 and Delta Subunit Gene Expression Is Associated with Greater Efficacy of Ethanol on Steroidogenesis and GABA-A Receptor Function Journal of Neurochemistry · 2006
    4. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    5. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    6. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999

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