Enhanced Sensitivity to Ethanol-Induced Inhibition of LTP in CA1 Pyramidal Neurons of Socially Isolated C57BL/6J Mice: Role of Neurosteroids

    January 2011 in “ Frontiers in Endocrinology ”
    Giuseppe Talani, Giovanni Biggio, Enrico Sanna
    TLDR Social isolation makes mice more sensitive to alcohol's effects on brain function.
    The study examined the impact of social isolation (SI) on ethanol (EtOH)-induced inhibition of long-term potentiation (LTP) in the hippocampus of C57BL/6J mice. It found that SI led to decreased levels of neurosteroids, reducing neuronal excitability and enhancing EtOH's inhibitory effect on LTP. Ethanol at 40 mM significantly inhibited LTP in SI mice but not in group-housed mice, an effect linked to neurosteroid biosynthesis. Co-application with finasteride, a 5α-reductase inhibitor, prevented this inhibition. Progesterone treatment partially reversed SI-induced changes, suggesting neurosteroids' role in modulating these effects. The study highlighted the impact of social stress on brain function and its potential to alter responses to substances like ethanol.
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