Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats

December 2017 in “ CNS Neuroscience & Therapeutics ”

Li Li, Yunxiao Kang, Xiaoming Ji, Li Yingkun, Shuangcheng Li, Xiangjian Zhang, Huixian Cui, Geming Shi

finasteride dopaminergic system dopamine tyrosine hydroxylase substantia nigra ventral tegmental area Propecia

TLDR Finasteride affects young male rats' brain function and behavior negatively.

A study conducted on adolescent male rats found that the hair loss drug Finasteride inhibited the brain's dopaminergic system and open-field behaviors, resulting in reduced dopamine levels and decreased expression of tyrosine hydroxylase mRNA and protein in the substantia nigra and ventral tegmental area. This suggests potential negative effects on brain function and behavior in young males.

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research Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats

13 citations , December 2017 in “CNS Neuroscience & Therapeutics”

Finasteride affects young male rats' brain function and behavior negatively.

Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats

Research cited in this study

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