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    Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats

    December 2017 in “ CNS Neuroscience & Therapeutics ”
    Li Li, Yunxiao Kang, Xiaoming Ji … Geming Shi
    Studysummary In this study, finasteride was found to inhibit the dopaminergic system and reduce open-field behaviors in adolescent male rats by decreasing dopamine levels and related proteins.
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    Research cited in this study 7

    1. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
    2. Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress Schizophrenia Research · 2015
    3. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    4. Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood Psychoneuroendocrinology · 2009
    5. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    6. Treatment of Tourette’s Syndrome With Finasteride American Journal of Psychiatry · 2007
    7. Steroid 5α-Reductases and 3α-Hydroxysteroid Dehydrogenases: Key Enzymes in Androgen Metabolism Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism · 2001

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    1. Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats CNS Neuroscience & Therapeutics · 2017