Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats

    December 2017 in “ CNS Neuroscience & Therapeutics ”
    Li Li, Yunxiao Kang, Xiaoming Ji, Li Yingkun, Shuangcheng Li, Xiangjian Zhang, Huixian Cui, Geming Shi
    Image of study
    TLDR Finasteride affects young male rats' brain function and behavior negatively.
    A study conducted on adolescent male rats found that the hair loss drug Finasteride inhibited the brain's dopaminergic system and open-field behaviors, resulting in reduced dopamine levels and decreased expression of tyrosine hydroxylase mRNA and protein in the substantia nigra and ventral tegmental area. This suggests potential negative effects on brain function and behavior in young males.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community I've been afflicted by post finasteride syndrome, what now?

      in Finasteride  44 upvotes 7 years ago
      A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.

      community This sub is very toxic towards people who don’t blindly follow the fin mafia

      in Treatment  226 upvotes 2 years ago
      The conversation criticizes the negative attitude towards those concerned about side effects from hair loss treatments like finasteride and minoxidil, or who prefer natural remedies. Specific treatments discussed include finasteride, minoxidil, rosemary oil, and RU58841, with an agreement that finasteride and minoxidil are proven effective.

      community Finasteride does deplete important nuero-active steroids

      in Research/Science  11 upvotes 2 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  109 upvotes 2 weeks ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

    Related Research

    1 / 1 results