Androgens and the Menopause

The document from 1998 reviews the potential benefits of androgen replacement therapy, specifically testosterone, for postmenopausal women. It highlights that menopause leads to a significant drop in oestradiol levels, which is often treated with oestrogen-based hormone replacement therapy (HRT). However, the review points out that declining androgen levels can lead to symptoms such as impaired sexual function, reduced well-being, and loss of energy, as well as negative effects on bone mass. The review suggests that testosterone replacement could be beneficial for sexual function and bone density in these women, although there is no data on its impact on fracture incidence. It also mentions that testosterone replacement may improve symptoms in women with rheumatoid arthritis but notes the potential risks of virilization and metabolic side effects, which are rare if hormone levels are maintained within the normal female range. The document concludes that while testosterone is important for both sexes, therapy for women has been limited by the lack of suitable preparations, and future developments may improve treatment options.