What Is the Rationale for Androgen Therapy for Women?

The 2003 document discusses the use of androgen therapy in women, particularly for those with female androgen insufficiency (FAI), which is characterized by symptoms like reduced libido, diminished well-being, and lowered mood. Testosterone replacement has been reported to alleviate these symptoms without significant adverse effects. Androgens, including testosterone, decline with age and have important physiological roles in women. The document notes that while testosterone therapy has been shown to improve mood, sexual function, and bone health in women, there is a lack of clear guidelines for diagnosis and treatment, and the long-term safety is not fully understood. It also mentions the potential risks of androgen therapy, such as masculinizing effects and changes in lipid concentrations. The document calls for more research to define normal androgen levels, establish the safety and efficacy of testosterone therapy, and understand the health consequences of low androgen levels. The work was supported by the Jean Hailes Foundation and involved a clinical investigator for Procter and Gamble and a consultant for Acrux Ltd.