Androgen Replacement in Women: A Commentary

In the 1999 commentary, Susan Davis discussed the potential benefits of androgen replacement therapy, particularly testosterone, for postmenopausal women experiencing symptoms like fatigue, low libido, and diminished well-being, which may be linked to low levels of bioavailable testosterone. The commentary noted that testosterone replacement could significantly improve these symptoms and quality of life, but the mechanisms of its effects were unclear. It highlighted the scarcity of data and the need for more research, including a definition of androgen deficiency in women. The document also explored potential new uses for androgen therapy, such as in cases of premature ovarian failure, premenstrual syndrome, and autoimmune diseases, while acknowledging the lack of clinical guidelines and the necessity for careful monitoring to avoid adverse effects. The conclusion was that androgen therapy could be beneficial for women with certain symptoms, but more research was needed to understand its effects fully, especially concerning PMS and the risk of breast cancer.