Testosterone Therapy in Premenopausal Women

The 2006 document reviews the use of testosterone therapy in premenopausal women, noting its potential benefits for conditions like hypothalamic amenorrhea, premature ovarian failure, and oophorectomy, as well as for improving bone and muscle mass, mood, well-being, and libido. It cites studies, including one by Goldstat et al. with 31 participants, showing improvements in well-being, mood, and sexual function with testosterone treatment. Another study mentioned used a transdermal patch delivering 150 µg/d of testosterone and found it well-tolerated. Despite these findings, the document emphasizes the lack of long-term safety data and the occurrence of side effects such as hirsutism and acne. It concludes that more research is needed to establish the safety and effectiveness of testosterone therapy in premenopausal women, and that those undergoing treatment should be informed of potential risks and benefits or be part of clinical trials.