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research Androgen insufficiency in women: diagnostic and therapeutic implications

59 citations , August 2004 in “Human Reproduction Update”

This article discusses the challenges in diagnosing female androgen insufficiency syndrome due to unreliable testosterone measurement methods but notes symptom improvement with testosterone therapy, emphasizing the need for women-specific formulations and safety guidelines.

research What is the Rationale for Androgen Therapy for Women?

20 citations , January 2003 in “Treatments in Endocrinology”

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

research Androgens and Female Sexual Function and Dysfunction—Findings From the Fourth International Consultation of Sexual Medicine

75 citations , February 2016 in “The Journal of Sexual Medicine”

This review highlights the efficacy of transdermal testosterone therapy in improving sexual function in women with hypoactive sexual desire disorder, though approved formulations and long-term safety data are limited.

research Androgen replacement therapy in women

1 citations , September 2012 in “Expert Review of Endocrinology & Metabolism”

This review discusses the clinical implications of female androgen deficiency and evaluates treatment options, emphasizing the need for cautious use of replacement therapy in women with severe deficiency and matching symptoms.

research HRT for women with premature ovarian insufficiency: a comprehensive review

61 citations , January 2017 in “Human Reproduction Open”

This review discusses hormone replacement therapy for women with premature ovarian insufficiency, strongly recommending it for symptom relief and bone protection, but notes a lack of evidence on optimal types and doses.

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community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Why is Minoxidil not enough for hair loss? (No fin)

59 upvotes 1 year ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community Dutasteride causing us to have… girl babies?

in Finasteride/Dutasteride 26 upvotes 3 years ago

User Kylo313 used dutasteride for 20 years and had two daughters, questioning if dutasteride affects the likelihood of having male vs female children. Replies mostly request hairline photos and discuss anecdotal experiences, with some suggesting correlation doesn't imply causation and that gender determination isn't affected by dutasteride.

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 3 years ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community How to cope with starting fin/dut too late

8 upvotes 11 months ago

Regret over not starting hair loss treatments like finasteride and minoxidil earlier, leading to significant hair loss. Users discuss coping strategies, including buzzing hair, staying on medications, and considering future treatments.

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Learn

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learn Spironolactone

Blood-pressure and diuretic drug with anti-androgen effects

Who is spironolactone used for in androgen-related hair thinning, and who should avoid it? Studies of spironolactone for hair loss are mostly in adult women; its use is off-label, it is avoided in pregnancy and generally not used in men, and the US label advises potassium checks (DailyMed, Aldactone).
How does spironolactone help reduce hair loss when used in topical or oral treatments? Spironolactone is thought to slow androgen-driven follicle miniaturisation by blocking androgen receptors; the trials are small, mostly in women and mostly alongside minoxidil. It is a prescription drug and its use for hair loss is off-label.

learn Pyrilutamide

Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in men and women but is not approved for hair loss anywhere. Its sponsor reports one failed (2023) and one successful (2026) Phase III in men, none of it peer-reviewed; long-term safety is unknown, and anti-androgens are not considered appropriate in pregnancy.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Small studies have found that metformin lowers circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss, although its US label says it should not be used in women. The one randomised trial (74 women, 2025) found it added no benefit to oral minoxidil, and the drug needs liver monitoring because its label warns of severe and fatal liver injury; it is contraindicated in pregnancy.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

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