Clinical and Phototrichogrammatic Evaluation of Estradiol Replacement Therapy on Hair Growth in Postmenopausal Japanese Women with Female Pattern Hair Loss: A Pilot Study

    November 2023 in “ International Journal of Women's Dermatology ”
    Yujiro Endo, Yuko Obayashi, Michiaki Murakoshi … Rie Ueki
    Studysummary In this study, female patients undergoing hormone replacement therapy showed improvements in frontal hairline appearance and increased hair plucking strength, suggesting positive effects of estradiol on hair growth while excluding age-related factors.
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    Research cited in this study 17

    1. Prevalence of Low Serum Vitamin D Levels in Patients Presenting With Androgenetic Alopecia: A Review Cureus · 2021
    2. Efficacy of Finasteride in Female Pattern Hair Loss: A Meta-Analysis Annals of Dermatology · 2021
    3. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    4. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    5. Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss Journal of Dermatological Science · 2018
    6. The Ovariectomized Mouse Simulates the Pathophysiology of Postmenopausal Female Pattern Hair Loss Journal of Dermatological Science · 2017
    7. The Changes in the Hair Cycle During Gestation and the Post-Partum Period Journal of the European Academy of Dermatology and Venereology · 2013
    8. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    9. Hormonal Changes in Menopause: Do They Contribute to a Midlife Hair Crisis in Women? British Journal of Dermatology · 2011
    10. Topical Fulvestrant Solution Has No Effect on Male and Postmenopausal Female Androgenetic Alopecia: Results from Two Randomized, Proof-of-Concept Studies British Journal of Dermatology · 2007
    11. Female Pattern Hair Loss: Current Treatment Concepts PubMed · 2007
    12. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    13. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling Endocrinology · 2005
    14. Topical Estrogen Therapy for Androgenetic Alopecia in Menopausal Females Dermatology · 2004
    15. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    16. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    17. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996