Topical Fulvestrant Solution Has No Effect on Male and Postmenopausal Female Androgenetic Alopecia: Results from Two Randomized, Proof-of-Concept Studies

    November 2007 in “ British Journal of Dermatology ”
    J. Gassmueller, Rolf-Dieter Hoffmann, Andrew R. Webster
    Studysummary This study found that topical fulvestrant did not significantly improve hair growth parameters in men and postmenopausal women with androgenetic alopecia, unlike minoxidil, which was more effective in men.
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    Research cited in this study 18

    1. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    2. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006
    3. Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding Journal of Investigative Dermatology Symposium Proceedings · 2005
    4. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling Endocrinology · 2005
    5. Trichoscan: What Is New? Dermatology · 2005
    6. Estrogens And The Hair Follicle Journal der Deutschen Dermatologischen Gesellschaft · 2004
    7. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    8. Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage Journal of Investigative Dermatology · 2004
    9. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    10. Estrogen Receptor Alpha, But Not Estrogen Receptor Beta, Is Involved in the Regulation of Hair Follicle Cycling and Epidermis Thickness in Male Mice Journal of Investigative Dermatology · 2002
    11. 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2000
    12. Effects of 17-β-Estradiol and ICI 182 780 on Hair Growth in Various Strains of Mice Journal of Investigative Dermatology Symposium Proceedings · 1999
    13. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    14. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    15. On The Effect Of Estrogen Receptor Agonists And Antagonists On The Mouse Hair Follicle Cycle Journal of Investigative Dermatology · 1998
    16. On Photo-Stability of Oxybenzone Journal of Investigative Dermatology · 1998
    17. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996
    18. The Effects of Epilation and Hormones on the Activity of Rat Hair Follicles Journal of Experimental Zoology · 1975

    Related research 9

    1. Effectiveness of Multimodality Therapy Using Minoxidil and Microneedling for the Treatment of Alopecia: A Systematic Review and Meta-Analysis 2023
    2. Pediatric Androgenetic Alopecia: An Updated Review Journal der Deutschen Dermatologischen Gesellschaft · 2023
    3. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    4. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    5. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    6. The Use of Trichoscopy to Assess the Efficacy of Topical Minoxidil 2% Solution in Patients with Female Pattern Hair Loss Zagazig university medical journal · 2019
    7. The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review PubMed · 2019
    8. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    9. Topical Fulvestrant Solution Has No Effect on Male and Postmenopausal Female Androgenetic Alopecia: Results from Two Randomized, Proof-of-Concept Studies British Journal of Dermatology · 2007