Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss

April 2018 in “ Journal of Dermatological Science ”

Yujiro Endo, Yuko Obayashi, Tomoji Ono, Tetsushi Serizawa, Michiaki Murakoshi, Manabu Ohyama

estradiol ANGPT2 female pattern hair loss human dermal papilla cells ovariectomized mice hair growth therapeutic approach E2 FPHL DPCs

TLDR Adjusting estradiol-ANGPT2 levels can promote hair growth in female pattern hair loss.

The study investigated the role of the estradiol-ANGPT2 axis in female pattern hair loss (FPHL) using a mouse model. The researchers found that estradiol (E2) increased the expression of ANGPT2-related genes in human dermal papilla cells (DPCs), and that ovariectomized mice with FPHL had decreased ANGPT2 expression. Treatment with E2 or ANGPT2 was found to promote hair growth in the mouse model. The study suggests that modulating the estradiol-ANGPT2 axis may be a potential therapeutic approach for FPHL.

View this study on jdsjournal.com →

Discuss this study in the Community →

Research cited in this study

16 / 16 results

research The Ovariectomized Mouse Simulates the Pathophysiology of Postmenopausal Female Pattern Hair Loss

6 citations, April 2017 in “Journal of Dermatological Science”

Ovariectomized mice mimic postmenopausal hair loss, and estradiol helps maintain hair density.

research Hormonal Therapy in Female Pattern Hair Loss

21 citations, February 2017 in “International Journal of Women's Dermatology”

Hormonal therapies help treat female hair loss, but results are slow and vary.

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

12 citations, July 2014 in “Journal of Investigative Dermatology”

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

256 citations, October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Growing human skin cells in a 3D environment can stimulate new hair growth.

research Evidence-Based Treatments for Female Pattern Hair Loss: A Summary of a Cochrane Systematic Review

40 citations, October 2012 in “British Journal of Dermatology”

Minoxidil helps regrow hair in female pattern hair loss, but more research needed for other treatments.

research Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness

75 citations, December 2011 in “British Journal of Dermatology”

Female pattern hair loss can be treated with medications, surgery, and cosmetic products, considering its psychological impact.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations, February 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

95 citations, July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

research The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

47 citations, September 2008 in “British Journal of Dermatology”

Ludwig pattern hair loss in women results from varying sensitivity in hair follicles, causing fewer visible hairs.

research Hair Follicle Regeneration Using Grafted Rodent and Human Cells

96 citations, April 2007 in “Journal of Investigative Dermatology”

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

100 citations, June 2006 in “British Journal of Dermatology”

Hair loss severity relates to increased miniaturization in female pattern hair loss.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations, August 2004 in “Journal of Investigative Dermatology”

Hair loss causes stress and affects mental health; treatment and support needed.

research Topical Estrogen Therapy for Androgenetic Alopecia in Menopausal Females

22 citations, March 2004 in “Dermatology”

Topical estrogen helps hair growth in menopausal women with no major side effects.

Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

73 citations, June 2001 in “Endocrinology”

Prolactin affects when mice shed and grow hair.

research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

234 citations, February 2001 in “British Journal of Dermatology”

FPHL affects hair density and diameter, causing visible hair loss in older women.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations, April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

Similar Research

5 / 1000+ results

Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats

Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss

Research cited in this study

research The Ovariectomized Mouse Simulates the Pathophysiology of Postmenopausal Female Pattern Hair Loss

research Hormonal Therapy in Female Pattern Hair Loss

research Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

research Evidence-Based Treatments for Female Pattern Hair Loss: A Summary of a Cochrane Systematic Review

research Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

research The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

research Hair Follicle Regeneration Using Grafted Rodent and Human Cells

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

research Topical Estrogen Therapy for Androgenetic Alopecia in Menopausal Females

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

Related Community Posts Join

community Estradiol blood test on fin. Doctor dont want to give me the test.

community Does anyone manage to keep the estradiol under control while on fin ? I'm talking in the normal range

community Finasteride has increased my Estradiol (estrogen) levels by 51% percentage

community 2 months of difference with estradiol and spiro (4 months total w/ estradiol & spiro; 4 years of minoxidil and finasteride) (you should not take estradiol or spiro if you look manly and want to continue looking manly)

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

community Has anyone used topical estrogen or estradiol for hair loss and how effective was it?

Similar Research

research Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

research Female Pattern Hair Loss: An Overview with Focus on the Genetics

research Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases

research Effect of Cyclosporin on Hair-Existing Area of Nude Mice