Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss

April 2018 in “ Journal of Dermatological Science ”

Yujiro Endo, Yuko Obayashi, Tomoji Ono, Tetsushi Serizawa, Michiaki Murakoshi, Manabu Ohyama

estradiol ANGPT2 female pattern hair loss human dermal papilla cells ovariectomized mice hair growth therapeutic approach E2 FPHL DPCs

TLDR Adjusting estradiol-ANGPT2 levels can promote hair growth in female pattern hair loss.

The study investigated the role of the estradiol-ANGPT2 axis in female pattern hair loss (FPHL) using a mouse model. The researchers found that estradiol (E2) increased the expression of ANGPT2-related genes in human dermal papilla cells (DPCs), and that ovariectomized mice with FPHL had decreased ANGPT2 expression. Treatment with E2 or ANGPT2 was found to promote hair growth in the mouse model. The study suggests that modulating the estradiol-ANGPT2 axis may be a potential therapeutic approach for FPHL.

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Research cited in this study

research The Ovariectomized Mouse Simulates the Pathophysiology of Postmenopausal Female Pattern Hair Loss

research Hormonal Therapy in Female Pattern Hair Loss

research Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

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research Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

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