Remarks on the Hormonal Background of the Male Equivalent of Polycystic Ovary Syndrome

The paper "Remarks on the Hormonal Background of the Male Equivalent of Polycystic Ovary Syndrome" discusses the hypothesis that there is a male equivalent to the female endocrine disease, polycystic ovarian syndrome (PCOS). This male form is characterized by changes in gonadotropin secretion, increased insulin resistance, and alterations in several steroid hormone levels. Clinical manifestations include premature androgenic alopecia (AGA). However, these symptoms are not always present in genetically predisposed men, suggesting that understanding of the male equivalent of PCOS needs to be expanded. This could be achieved by measuring adrenal 11-oxygenated C19 steroids, particularly 11-keto-, and 11β-hydroxy-derivatives of testosterone and dihydrotestosterone, focusing on the skin's role as an endocrine organ, and confirming any age-related factors in glucose metabolism disorders in such predisposed men.