Androgens and Androgen Receptor in the Management of Skin Diseases

January 2022 in “ Journal of Biosciences and Medicines ”

X. K. Zhou, Junsheng Yu, Wenqiang Zhang, Wenhai Li

androgens androgen receptor AR acne androgenetic alopecia AGA pilosebaceous unit PSU sebum production CAG polymorphism Clascoterone androgen receptor inhibitor hair follicle shrinkage antiandrogen therapies androgen-independent therapies hirsutism

Studysummary This review discusses the roles of androgens and androgen receptor in skin diseases like acne and hirsutism, and highlights the promise of antiandrogen drugs, reporting no new clinical findings.

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Research cited in this study

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research What's New in Therapy for Male Androgenetic Alopecia?

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research The State-of-the-Art in the Management of Androgenetic Alopecia: A Review of New Therapies and Treatment Algorithms

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research Androgen Receptor Inhibits the Hair Follicle Induction Potential of Dermal Papilla Cells by Binding with Tcf4 at the A574 Binding Site

4 citations , May 2022 in “Genes & Diseases”

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17 citations , November 2021 in “Journal of Cosmetic Dermatology”

This review discusses treatment options for androgenetic alopecia, highlighting the need for personalized, evidence-based approaches but reports no new clinical results.

research Clascoterone: First Approval

27 citations , October 2020 in “Drugs”

This article reviews the development milestones of clascoterone up to its first approval for treating acne vulgaris, reporting no new clinical results for androgenetic alopecia.

research Topical Ketoconazole for the Treatment of Androgenetic Alopecia: A Systematic Review

11 citations , December 2019 in “Dermatologic Therapy”

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research Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting

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research The Efficacy and Use of Finasteride in Women: A Systematic Review

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This review found that while finasteride may improve female pattern hair loss and hirsutism in women, more long-term studies are needed to optimize its use and assess potential consequences.

research Androgens in Women: Role in Androgen-Mediated Cutaneous Disorders

56 citations , October 2018 in “Journal of The American Academy of Dermatology”

This review discusses the role of androgens in women's skin-related conditions like acne, hirsutism, and female pattern hair loss, noting the lack of dermatology guidelines for when to pursue endocrinologic evaluation.

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19 citations , March 2018 in “JAMA”

This guideline discusses the evaluation and treatment of hirsutism in premenopausal women, recommending oral contraceptive pills or antiandrogens as initial therapies with weak support from low-quality evidence.

research Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

80 citations , December 2017 in “International Journal of Dermatology”

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Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

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This study found that antiandrogenic therapy with Melleva 35 for three months was effective in reducing hair loss and improving acne in women with both Androgenetic Alopecia and Acne Vulgaris.

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This study found that androgen/androgen receptor signaling accelerates premature senescence in dermal papilla cells, highlighting a potential target for treating androgenetic alopecia.

research The Role of Androgen and Androgen Receptor in Skin-Related Disorders

124 citations , July 2012 in “Archives of Dermatological Research”

This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.

research Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia

41 citations , October 2011 in “Journal of Dermatology”

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research Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials

150 citations , February 2008 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

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research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

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research Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

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