Reversal of Androgenetic Alopecia by Topical Ketoconazole: Relevance of Anti-Androgenic Activity

September 2006 in “ Journal of Dermatological Science ”

Shigeki Inui, Satoshi Itami

androgenetic alopecia topical ketoconazole androgen receptors hair regrowth anti-androgenic activity AGA KCZ AR

TLDR Ketoconazole lotion can improve hair regrowth for some people with androgenetic alopecia.

This study was conducted to determine the effectiveness of topical ketoconazole (KCZ) in treating androgenetic alopecia (AGA). Six Japanese males with AGA were enrolled and applied KCZ lotion almost every day during or immediately after hair washing. After 6-10 months, two of the men showed significant improvement in hair regrowth, suggesting that KCZ is effective for some individuals with AGA. To explain this effect, transient transfection assays using CV-1 cells transfected with androgen receptors (AR) suggested that KCZ suppresses AR activity which could improve AGA.

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4 / 4 results

Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

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Reversal of Androgenetic Alopecia by Topical Ketoconazole: Relevance of Anti-Androgenic Activity

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