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research Mitochondrial Dysfunction in Diabetic Neuropathy May Be Involved in the Development of Neuropathic Pain via a Reduction in Neurosteroid Synthesis

4 citations , April 2017 in “F1000Research”

Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.

Sex Differences in Steroid Levels and Steroidogenesis in the Nervous System: Physiopathological Role

research Sex Differences in Steroid Levels and Steroidogenesis in the Nervous System: Physiopathological Role

35 citations , November 2019 in “Frontiers in Neuroendocrinology”

Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.

research Role of Neurosteroids in Dopaminergic Modulation

May 2015

Neurosteroids help control dopamine responses in the brain.

research Mitochondrial Dysfunction in an Animal Model of Diabetic Neuropathy Is Associated with a Reduction of Neurosteroid Synthesis

1 citations , March 2018 in “F1000Research”

Diabetic neuropathy in mice is linked to poor mitochondria function and lower brain hormone production.

research Inhibition of 17α-Hydroxylase/C17,20 Lyase Reduces Gating Deficits Consequent to Dopaminergic Activation

19 citations , September 2013 in “Psychoneuroendocrinology”

Blocking CYP17A1 enzyme may help improve certain brain function issues related to dopamine.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 1 year ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.