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Cutaneous Application of Alpha-Methylspermidine Activates the Growth of Resting Hair Follicles in Mice

research Cutaneous application of α-methylspermidine activates the growth of resting hair follicles in mice

12 citations , December 2009 in “Amino Acids”

In this study, topical application of α-methylspermidine during the telogen phase in mice induced hair growth by increasing the polyamine pool and mimicking the anagen phase's characteristics.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

research Immunization by Application of DNA Vaccine onto a Skin Area Wherein the Hair Follicles Have Been Induced into Anagen-onset Stage

20 citations , August 2007 in “Molecular therapy”

This study found that inducing hair follicles into the anagen-onset stage in mice enhances the immune response to a topically applied DNA vaccine against anthrax.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

6 citations , November 2013 in “International Journal of Radiation Biology”

In this study, γ-ray irradiation of mice reduced hair follicle density and pigmentation, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.

research Alopecia: what to do when the endocrine skin tests are normal?

May 2021 in “British Small Animal Veterinary Association eBooks”

This review discusses various causes and patterns of canine alopecia, noting that symmetrical and diffuse hair loss often indicates an endocrinopathy, and reports no new clinical results.

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Community Join

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community Realistically, how much PP405 will cost?

33 upvotes 1 year ago

PP405 is in phase 2 trials for hair loss, with discussions on its cost and effectiveness compared to minoxidil and finasteride. Users are skeptical about its efficacy and timeline, with hopes for market release by 2027.

community 3 months on finasteride and hair density IS decreasing

in Finasteride/Dutasteride 43 upvotes 5 months ago

Finasteride can cause initial hair shedding as part of the treatment process, which is normal and often leads to regrowth of healthier hair. Users discuss experiencing multiple shedding phases and emphasize patience, as results can take several months to become noticeable.

community Stop the fear mongering of oral minoxidil its one of the best treatments available in 2020. It does not cause heart lesions or adverse cardiac effects like people claim. I am maintaining with just oral minoxidil with retrograde alopecia and diffuse thinning all over nw3 hairline

78 upvotes 6 years ago

Oral minoxidil is considered a safe and effective treatment for hair loss at low dosages, with minimal cardiac risks. Users report positive results, though some experience side effects like increased heart rate and skin changes, and consulting a doctor is advised.

community Dutasteride switch after 8 months made my hair worse (With picture proof)

in Research/Science 62 upvotes 1 year ago

Switching to Dutasteride worsened hair condition, causing shedding and inflammation. The user will continue Dutasteride until 18 months before possibly switching back to Finasteride, while using oral Minoxidil.

community Redensyl for Hair Loss — What It Can and Can’t Do

9 months ago

Redensyl is a plant-based treatment that may support hair regrowth by reactivating dormant follicles and improving hair density, especially in early-stage thinning. It is not a miracle cure and results vary; it is less proven than Minoxidil or Finasteride and may cause scalp irritation.

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Learn

6 / 13 results

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Vascular Endothelial Growth Factor

learn sh-Polypeptide-7

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stemoxydine

How does stemoxydine help stimulate new hair growth on the scalp? Stemoxydine stimulates new hair growth by promoting hair follicles to transition from the resting phase to the active growth phase.

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Clinics

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