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    Glossary Stem Cell Factor

    protein crucial for stem cell survival and differentiation

    Stem Cell Factor (SCF), also known as Kit Ligand, is a protein that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells, which are the cells responsible for forming blood. SCF binds to the c-Kit receptor on the surface of these stem cells, activating signaling pathways that are essential for their function and maintenance. This factor is also important in other biological processes, including pigmentation, fertility, and the development of certain cell types in the immune system.

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    1. Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair follicles Journal of Endocrinology · 2008 · 39 citations
    2. Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts Laboratory Investigation · 2006 · 27 citations
    3. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations Acta Histochemica Et Cytochemica · 2010 · 10 citations
    4. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024 · 4 citations
    5. The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells International Journal of Molecular Sciences · 2020 · 3 citations
    6. Stem cell factor combined with matrix proteins promotes attachment and migration of amelanotic melanocyte from human follicle hair Linchuang pifuke zazhi · 2006
    7. Immunohistochemical study assessing stem cell factor receptor C-kit in patients with alopecia Egyptian Journal of Dermatology and Venereology · 2020
    8. The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates Nature cell biology · 2023 · 6 citations
    9. Efficacy of Platelet-Rich Plasma versus Mesotherapy with Recombinant Growth Factors and Stem Cell-Conditioned Media in Androgenetic Alopecia: A Retrospective Study Skin Appendage Disorders · 2024
    10. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    11. Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice Nature · 2015 · 321 citations
    12. ACOS23O-002: The Use of Bone Marrow Mesenchymal Stem Cell Derived Cytokines and Growth Factors in The Management of Androgenetic Alopecia Journal of Asia Pacific Aesthetic Sciences · 2023
    13. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    14. The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome Frontiers in cell and developmental biology · 2023
    15. Epidermal growth factor promotes mesenchymal stem cell-mediated wound healing and hair follicle regeneration. PubMed · 2017 · 4 citations
    16. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    17. Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    18. Synovial membrane mesenchymal stem cell [SM-MSC] induced IGF-1 promote growth factor release in conditioned medium SM-MSC IOP Conference Series Earth and Environmental Science · 2021 · 2 citations
    19. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    20. Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation Experimental and Therapeutic Medicine · 2017 · 6 citations
    21. The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function Oncogene · 2022 · 3 citations
    22. Mapping the expression of epithelial hair follicle stem cell‐related transcription factors LHX2 and SOX9 in the human hair follicle Experimental Dermatology · 2015 · 33 citations
    23. What does the concept of the stem cell niche really mean today? BMC biology · 2012 · 163 citations
    24. Generation of trichogenic adipose-derived stem cells by expression of three factors Journal of Dermatological Science · 2018 · 12 citations
    25. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    26. Exploration of <i>Aloe vera</i>, <i>Centella asiatica</i>, Green Tea, and <i>Pueraria mirifica</i> Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells Natural Product Communications · 2025
    27. H2AK119ub dynamics control hair follicle stem cell quiescence Nature Communications · 2025 · 2 citations
    28. The stem cell niche The Journal of Pathology · 2008 · 209 citations
    29. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    30. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations