Expression of Long Noncoding RNA HOTAIR and MicroRNA-205 and Their Relation to Transforming Growth Factor Beta 1 in Patients with Alopecia Areata

January 2023 in “ Skin Appendage Disorders ”

Noha Ezzat Mohamad, Ahmed MB. Khedr, Olfat Shaker, Mohammed Hassan

TLDR Changes in certain RNA and protein levels may contribute to alopecia areata and could be treatment targets.

This study investigated the expression levels of long noncoding RNA HOTAIR and microRNA-205, as well as their relationship with transforming growth factor β1 (TGF-β1) in patients with alopecia areata (AA). The case-control study included 50 AA patients and 50 healthy controls. Results showed that lncRNA HOTAIR was significantly downregulated, while miRNA-205 and TGF-β1 were significantly upregulated in AA patients. These findings suggested that the altered expression of these molecules could play a role in the pathogenesis of AA and might serve as potential therapeutic targets for treatment.

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