Assessment Of MiR-19b-3p, MiR-182-5p, And MiR-155-5p Expression And Its Relationship With Alopecia Areata Severity

March 2025 in “ Archives of Dermatological Research ”

Ahmed Ibrahim AbdElneam, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj, Ghada Farouk Mohammed, Lina Mohammed Atef

miR-19b-3p miR-182-5p miR-155-5p alopecia areata AA biomarkers diagnostic markers disease severity upregulated AUC disease progression targeted therapies hair loss alopecia

TLDR miR-155-5p can help diagnose and track alopecia areata severity.

This study examines the expression of miR-19b-3p, miR-182-5p, and miR-155-5p in 67 alopecia areata (AA) patients compared to 62 healthy controls to evaluate their potential as diagnostic markers and indicators of disease severity. The findings reveal that these miRNAs are significantly upregulated in AA patients, with miR-19b-3p, miR-182-5p, and miR-155-5p showing high diagnostic accuracy (AUC values of 0.99, 0.95, and 0.97, respectively). Importantly, miR-155-5p expression is significantly correlated with AA severity, indicating its potential as a marker for disease progression. These results suggest that these miRNAs, especially miR-155-5p, could serve as minimally invasive biomarkers for diagnosing and monitoring AA, potentially aiding in the development of targeted therapies.

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research Genetic Basis of Alopecia Areata

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