Identification of Potential Hub Genes in Alopecia Areata

October 2024 in “ Experimental Dermatology ”

Runqiu Liu, Longdan Liu, Jiandan Xu, Xiaoting Wen, Yannan Jiang, Qi Qi, Jie Qin, Pingping Qin

alopecia areata cytokines chemokines hair follicle development protein-protein interaction network hub genes differentially expressed genes long non-coding RNAs mRNA-miRNA-lncRNA regulatory network CD8A mir-185-5p FOXD2-AS1 AA DEGs DElncRs PPI network

Studysummary In this study, researchers identified 173 differentially expressed genes in alopecia areata patients linked to immune and hair follicle pathways, constructed a regulatory network involving mRNA, miRNA, and lncRNA, and highlighted CD8A and FOXD2-AS1 as potential diagnostic markers and therapeutic targets.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigates the genetic basis of alopecia areata (AA), an immune-mediated chronic hair loss condition, by analyzing gene expression data from AA patients and healthy controls. Researchers identified 173 differentially expressed genes (DEGs) enriched in pathways related to cytokines, chemokines, and hair follicle development. Through protein-protein interaction (PPI) network analysis and validation with three additional datasets, 24 hub genes were identified, with five being upregulated. The study also identified 26 differentially expressed long non-coding RNAs (DElncRs), including nine upregulated ones in the cytoplasm. A regulatory network involving mRNA, miRNA, and lncRNA was constructed, highlighting the potential roles of CD8A, mir-185-5p, and FOXD2-AS1 in AA pathogenesis. CD8A and FOXD2-AS1 were suggested as potential diagnostic markers and therapeutic targets for AA.

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Research cited in this study

17 / 17 results

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