A Functional Role of S100A4/Non-Muscle Myosin IIA Axis for Pro-Tumorigenic Vascular Functions in Glioblastoma

    April 2022 in “ Cell Communication and Signaling ”
    Madoca Inukai, Ako Yokoi, Yuuki Ishizuka, Miki Hashimura, Toshihide Matsumoto, Yasuko Oguri, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Toshihiro Kumabe, Makoto Saegusa
    TLDR High S100A4 levels worsen glioblastoma by promoting blood vessel growth.
    The study explored the S100A4/non-muscle myosin IIA (NMIIA) axis in glioblastoma (GBM) using 94 samples, revealing that S100A4 overexpression was linked to increased microvascular density and poor survival outcomes. S100A4(+)/HIF-1α(−) cells enhanced tumor progression by promoting vascular functions through NMIIA inhibition and VEGF release. Hypoxia-induced S100A4 expression was associated with increased cell mobility and vascularization, with high S100A4 levels correlating with worse prognosis. The study highlighted the potential of targeting the S100A4/NMIIA axis for therapeutic intervention in GBM.
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