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research Blockade of S100A3 activity inhibits murine hair growth

1 citations , January 2015 in “Genetics and Molecular Research”

This study demonstrated that blocking S100A3 in mice inhibited hair growth by delaying the anagen phase and reducing the number of hair follicles, suggesting S100A3 as a potential target for hair loss treatments.

research RAGE and Its Ligands in Melanoma

1 citations , April 2015 in “InTech eBooks”

RAGE is a potential target for melanoma treatment, but its effectiveness is uncertain due to variable expression levels.

research Invasion and increased expression of S100A4 and CYR61 in mesenchymal transformed breast cancer cells is downregulated by GnRH

21 citations , April 2016 in “International Journal of Oncology”

This study found that treatment with the GnRH agonist Triptorelin significantly decreased invasion and expression of S100A4 and CYR61 in certain breast cancer cells, suggesting a potential role in slowing cancer progression.

research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

September 2025 in “Arthritis Research & Therapy”

In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.