Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells
February 2006
in “
American journal of physiology. Cell physiology
”
matriptase HAI-1 steroid sex hormones 17beta-estradiol prostate cancer cells breast cancer cells 5alpha-dihydrotestosterone DHT androgen antagonist bicalutamide RNA transcription inhibitor actinomycin D protein synthesis inhibitor cycloheximide androgen receptor estradiol testosterone androgen Proscar Propecia
Studysummary This study observed that in hormone-starved prostate cancer cells, the androgen 5alpha-dihydrotestosterone rapidly induces matriptase activation and shedding, which involves androgen receptor signaling and requires both transcription and protein synthesis.
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