TLDR Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.
In 2009, researchers developed and evaluated a series of prostate-specific membrane antigen (PSMA)-targeted 99mTc-radioimaging agents for prostate cancer detection. They synthesized six agents, with three showing low nanomolar affinity for PSMA-expressing LNCaP cells and selective localization to LNCaP tumor xenografts in mice. The most promising agent demonstrated 12.4% injected dose per gram of tumor tissue at 4 hours post-injection with high tumor-to-muscle ratios, indicating its potential for clinical imaging applications. The study concluded that these agents, particularly the most effective compound, could be promising for PSMA-targeted radioimaging of prostate cancer.
89 citations,
December 2006 in “Lancet Oncology” Taking 1 mg/day finasteride for hair loss significantly lowers PSA levels in men, which may affect prostate cancer screening.
4 citations,
March 2018 in “Journal of labelled compounds & radiopharmaceuticals” A new compound was effective for imaging prostate cancer in rats.
2 citations,
February 2023 in “BJUI” Urologists should monitor mental health in patients taking finasteride due to potential links to suicidal thoughts, adjusting dosage or stopping use if necessary. More research is needed to confirm if finasteride causes these thoughts.
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December 2009 in “Therapeutic Advances in Medical Oncology” The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.
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October 2018 in “Elsevier eBooks” Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.
December 2023 in “Research and reports in urology” A young man with high-grade prostate cancer had successful surgery and good recovery, highlighting the need for awareness in younger men.
