Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

    March 2018 in “ Journal of labelled compounds & radiopharmaceuticals ”
    Syed Qaiser Shah, Gul‐e‐Raana, Ghias Uddin
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    TLDR A new compound was effective for imaging prostate cancer in rats.
    In 2018, researchers modified finasteride to create a new compound, finasteride dithiocarbamate, and its rhenium and technetium-99m tricarbonyl complexes, to explore their potential as imaging agents for prostate cancer (PCa) in a rat model. The new compound was synthesized and its identity was confirmed through various analytical techniques. The technetium-99m labeled compound demonstrated high radiochemical purity and stability at room temperature and in serum. Preclinical studies showed that this compound had a high uptake in the prostate of rats with histopathologically confirmed PCa, suggesting its potential for noninvasive imaging of PCa in vivo.
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