Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

March 2018 in “ Journal of labelled compounds & radiopharmaceuticals ”

Syed Qaiser Shah, Gul‐e‐Raana, Ghias Uddin

finasteride finasteride dithiocarbamate technetium-99m rhenium prostate cancer PCa radiochemical purity serum preclinical studies in vivo Propecia

TLDR A new compound was effective for imaging prostate cancer in rats.

In 2018, researchers modified finasteride to create a new compound, finasteride dithiocarbamate, and its rhenium and technetium-99m tricarbonyl complexes, to explore their potential as imaging agents for prostate cancer (PCa) in a rat model. The new compound was synthesized and its identity was confirmed through various analytical techniques. The technetium-99m labeled compound demonstrated high radiochemical purity and stability at room temperature and in serum. Preclinical studies showed that this compound had a high uptake in the prostate of rats with histopathologically confirmed PCa, suggesting its potential for noninvasive imaging of PCa in vivo.

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Research cited in this study

2 / 2 results

Effect of 1 mg/Day Finasteride on Concentrations of Serum Prostate-Specific Antigen in Men With Androgenic Alopecia: A Randomized Controlled Trial

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research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

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research Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

4 citations, March 2018 in “Journal of labelled compounds & radiopharmaceuticals”

A new compound was effective for imaging prostate cancer in rats.