Anti-Androgenicity of Flutamide and Its Metabolite SCH 16423

June 1979 in “ Biochemical Society Transactions ”

R. Neri, Edwin A. Peets, Arthur S. Watnick

Flutamide Sch 16423 anti-androgenic androgenic alopecia androgen activity androgen-related disorders

TLDR Flutamide and its metabolite can effectively reduce androgen effects.

The study from 1979 investigated the anti-androgenic properties of Flutamide and its metabolite Sch 16423. The researchers, Rudolph Neri, Edwin Peets, and Arthur Watnick from Schering Research Division, found that both compounds effectively inhibited androgen activity. This was significant for potential treatments of conditions like prostate cancer and androgenic alopecia, where reducing androgen effects could be beneficial. The findings supported the use of Flutamide and its metabolite as therapeutic agents in managing androgen-related disorders.

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community Monthly Reminder.

7 upvotes 6 years ago

Various treatments for male pattern baldness including Minoxidil, Finasteride/Dutasteride, hair systems, and oral anti-androgens such as Spironolactone and Flutamide. It also mentions dermarolling as a possible treatment in conjunction with minoxidil.

community Any balding females? I need advice with coping :(

16 upvotes 8 years ago

A 27-year-old woman is struggling with hair loss, feeling self-conscious and seeking advice on coping. She mentions trying Minoxidil but is hesitant due to scalp issues and is looking for ways to regain confidence.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 5 upvotes 3 weeks ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community Are these all the anti androgen products?

in Treatment 6 upvotes 1 year ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

community Overwhelming amount of anti-androgens

in Female 1 year ago

The conversation discusses the effectiveness of anti-androgens for hair loss, with a preference for topical treatments like RU58841 over oral options due to better scalp concentration and fewer side effects. Topical finasteride at 0.1% may provide some results, especially when combined with a topical androgen receptor antagonist like RU58841.