Anti-Androgenicity of Flutamide and Its Metabolite SCH 16423

    June 1979 in “ Biochemical Society Transactions ”
    R. Neri, Edwin A. Peets, Arthur S. Watnick
    TLDR Flutamide and its metabolite can effectively reduce androgen effects.
    The study from 1979 investigated the anti-androgenic properties of Flutamide and its metabolite Sch 16423. The researchers, Rudolph Neri, Edwin Peets, and Arthur Watnick from Schering Research Division, found that both compounds effectively inhibited androgen activity. This was significant for potential treatments of conditions like prostate cancer and androgenic alopecia, where reducing androgen effects could be beneficial. The findings supported the use of Flutamide and its metabolite as therapeutic agents in managing androgen-related disorders.
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