Anti-Androgenicity of Flutamide and Its Metabolite SCH 16423

June 1979 in “ Biochemical Society Transactions ”

R. Neri, Edwin A. Peets, Arthur S. Watnick

Flutamide Sch 16423 anti-androgenic androgenic alopecia androgen activity androgen-related disorders

TLDR Flutamide and its metabolite can effectively reduce androgen effects.

The study from 1979 investigated the anti-androgenic properties of Flutamide and its metabolite Sch 16423. The researchers, Rudolph Neri, Edwin Peets, and Arthur Watnick from Schering Research Division, found that both compounds effectively inhibited androgen activity. This was significant for potential treatments of conditions like prostate cancer and androgenic alopecia, where reducing androgen effects could be beneficial. The findings supported the use of Flutamide and its metabolite as therapeutic agents in managing androgen-related disorders.

View this study on portlandpress.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Therapeutic Control of Androgen Action

7 citations, January 1994 in “Annual Reports in Medicinal Chemistry”

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

88 citations, February 2008 in “Journal of Medicinal Chemistry”

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

16 citations, October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research Androgen Antagonists in Androgen Target Tissues

27 citations, January 1984 in “Pharmacology & Therapeutics”

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

research Clinical Applications of Antiandrogens

29 citations, October 1988 in “Journal of Steroid Biochemistry”

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Anti-Androgenicity of Flutamide and Its Metabolite SCH 16423

Related Community Posts Join

community Monthly Reminder.

community Any balding females? I need advice with coping :(

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

community Are these all the anti androgen products?