Therapeutic Control of Androgen Action

    January 1994 in “ Annual Reports in Medicinal Chemistry ”
    Gary H. Rasmusson, Jeffrey H. Toney
    Studysummary This review discusses hormonal manipulation for conditions like prostatic disorders and skin issues and highlights promising treatments like casodex and finasteride, but it reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 16

    1. Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial Fertility and Sterility · 1994
    2. Finasteride The New England Journal of Medicine · 1994
    3. RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994
    4. Finasteride: The First 5α-Reductase Inhibitor Pharmacotherapy · 1993
    5. Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    6. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993
    7. Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 1993
    8. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993
    9. The Antiandrogens Dermatologic Clinics · 1993
    10. Four-Amino Acid Segment in Steroid 5 Alpha-Reductase 1 Confers Sensitivity to Finasteride, a Competitive Inhibitor Journal of Biological Chemistry · 1992
    11. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992
    12. Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque The Journal of Clinical Endocrinology and Metabolism · 1992
    13. Effects of Flutamide and Finasteride on Rat Testicular Descent Endocrinology · 1991
    14. Chapter 20: Pathogenesis and Treatment of Alopecias Annual Reports in Medicinal Chemistry · 1989
    15. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985
    16. Androgen Antagonists in Androgen Target Tissues Pharmacology & Therapeutics · 1984