Injectable Minoxidil for Hair Loss Disorders: A Systematic Review

This systematic review explores the potential of injectable minoxidil as a treatment for hair loss disorders, highlighting its 100% bioavailability when injected intradermally compared to the lower absorption rates of topical and oral forms. Minoxidil acts as a vasodilator, promoting hair growth by stimulating potassium channels and enhancing cell proliferation. The effectiveness of minoxidil, whether topical or oral, is influenced by the activity of sulfotransferase in hair follicles, which converts minoxidil into its active form, minoxidil sulfate. Injectable minoxidil offers a promising nonsurgical and minimally invasive option for hair loss treatment, with the potential to improve outcomes by extending the anagen phase and increasing follicular size.