Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

March 2021 in “ British Journal of Dermatology ”

R. Laufer Britva, Amit Keren, A. Ginzburg, Yehuda Ullmann, Ralf Paus, Amos Gilhar

androgenetic alopecia platelet-rich plasma hair regrowth hair shaft diameter vellus-to-terminal hair reconversion humanized mouse model AGA PRP

TLDR PRP helps hair regrowth and thickness.

This study used a humanized mouse model of androgenetic alopecia to investigate the effects of platelet-rich plasma (PRP) on hair growth. The results showed that PRP stimulated hair regrowth, increased hair shaft diameter, and converted vellus hairs to terminal hairs. These findings suggest that PRP may be a promising treatment for androgenetic alopecia. The study suggests that the humanized AGA mouse model can be a useful tool for further research on PRP treatment for AGA. However, further studies are needed to confirm these results in humans.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

research Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

13 citations, September 2020 in “International Journal of Molecular Sciences”

PRP therapy and minoxidil combo works best for male hair loss.

research Platelet-Rich Plasma for Androgenetic Alopecia: Efficacy Differences Between Men and Women

10 citations, August 2020 in “Dermatologic Therapy”

PRP improves hair thickness for both genders, but only increases hair density in men.

research Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial

33 citations, July 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

research A Review of the Treatment of Male Pattern Hair Loss

53 citations, February 2020 in “Expert Opinion on Pharmacotherapy”

Finasteride and minoxidil work best together for hair loss.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations, September 2015 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Related Community Posts Join

6 / 1000+ results

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 15 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community I have successfully stopped my hormone-induced hair loss ( caused by PCOS,) for 2 years now but I can't seem to be able to regrow the lost hair. Has anyone tried Platelet-Rich Plasma Therapy (PRP)?

in Female 6 upvotes 3 years ago

GentleIris stopped hormone-induced hair loss with diet changes but couldn't regrow lost hair. A reply suggested microneedling instead of Platelet-Rich Plasma Therapy (PRP) for hair regrowth.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Comparison of options: topical vs medication

in Female 1 upvotes 6 months ago

A user diagnosed with AGA is seeking advice on hair loss treatments, comparing topical Minoxidil, Spironolactone, and Finasteride to oral medications and natural methods like dermastamping, PRP, and LED light. They are concerned about side effects and effectiveness, especially given their existing fatigue.

community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

Related Research

6 / 6 results

Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

research Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

March 2021 in “British Journal of Dermatology”

PRP helps hair regrowth and thickness.

research Hair Loss and Hirsutism Management

January 2019

Low-level light therapy, possibly combined with other treatments, may become a leading hair loss treatment, while hirsutism often worsens with age and lacks preventive options.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

research Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.

1 citations, January 2017 in “Elsevier eBooks”

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research Disorders of Hair Growth: Diagnosis and Treatment

26 citations, January 1994 in “McGraw-Hill eBooks”

Many hair loss conditions can be treated.