TLDR Lack of TrkC receptor delays hair follicle development.
The study explored the impact of the TrkC receptor on hair follicle development by using TrkC knockout mice. It found that the absence of TrkC significantly delayed hair follicle morphogenesis, as indicated by earlier development stages and reduced skin thickness compared to wild-type mice. This suggested that neurotrophin-3 (NT-3) promoted hair follicle development through TrkC signaling, possibly involving Wnt and BMP pathways. The study had a small sample size, with 3 TrkC knockout and 3 wild-type mice, underscoring the role of NT-3/TrkC in hair follicle development.
271 citations
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March 1999 in “Developmental biology” The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.
148 citations
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October 1997 in “Journal of Investigative Dermatology” 29 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle development involves complex interactions between skin layers and cells, but many details are still unknown.
32 citations
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February 2019 in “eLife” BMP signaling is essential for the development of touch domes.
155 citations
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August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.
71 citations
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February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
86 citations
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December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
9 citations
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December 2021 in “Androgens” Androgens like testosterone may help treat traumatic brain injury by reducing mitochondrial stress and inflammation.
99 citations
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January 2004 in “Progress in brain research” Neurotrophins are important for hair growth and could help treat hair loss.
