Stimulation of Mouse Hair Regrowth by Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells

    July 2024 in “ Acta Histochemica ”
    Jing Wang, Qingmin Sun, Ya Shen, Qingshan Li, Yongjun Piao, Lin Gong
    TLDR Exosomes from human stem cells can help regrow hair in mice.
    The study investigates the effects of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) on hair regrowth in mice. The hUCMSC-exos were extracted and used to treat depilation-induced hair regrowth in C57BL/6 mice. Results showed that hUCMSC-exos significantly promoted fibroblast proliferation and accelerated hair regrowth by upregulating hair follicle stem/progenitor cells and activating the Wnt/β-catenin pathway. These findings suggest that hUCMSC-exos could be a potential therapeutic approach for treating hair loss disorders.
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