Stimulation of Mouse Hair Regrowth by Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells

July 2024 in “ Acta Histochemica ”

Jing Wang, Qingmin Sun, Ya Shen, Qingshan Li, Yongjun Piao, Lin Gong

exosomes human umbilical cord mesenchymal stem cells UCMSC-Exos hair regrowth mesenchymal stem cells regenerative properties therapeutic approach stem cell therapy

Studysummary This study investigates the potential of umbilical cord mesenchymal stem cells exosome (UCMSC-Exos) to promote hair growth, focusing on its mechanisms of action, though specific results are not reported.

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The study investigates the effects of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) on hair regrowth in mice. The hUCMSC-exos were extracted and used to treat depilation-induced hair regrowth in C57BL/6 mice. Results showed that hUCMSC-exos significantly promoted fibroblast proliferation and accelerated hair regrowth by upregulating hair follicle stem/progenitor cells and activating the Wnt/β-catenin pathway. These findings suggest that hUCMSC-exos could be a potential therapeutic approach for treating hair loss disorders.

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research Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1

February 2023 in “International Journal of Molecular Sciences”

This study found that exosomes derived from dermal papilla cells can enhance the proliferation of hair follicle stem cells by stimulating the LEF1 pathway, offering insights into hair follicle growth regulation.

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.

research A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

31 citations , August 2021 in “Stem Cell Research & Therapy”

This review examines the life cycle, biomarkers, and functions of hair follicle stem cells, emphasizing their role in hair loss therapy and other skin and hair disorders, but reports no new clinical results.

research Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration

19 citations , June 2021 in “Tissue Engineering and Regenerative Medicine”

This study found that adipose-derived stem cell exosomes promoted hair follicle regeneration in mice, resulting in a higher number of regenerated hairs and follicles compared to the control group.

Enhanced Cutaneous Wound Healing by Functional Injectable Thermo-Sensitive Chitosan-Based Hydrogel Encapsulated Human Umbilical Cord-Mesenchymal Stem Cells

research Enhanced Cutaneous Wound Healing by Functional Injectable Thermo-Sensitive Chitosan-Based Hydrogel Encapsulated Human Umbilical Cord-Mesenchymal Stem Cells

48 citations , July 2019 in “International Journal of Biological Macromolecules”

This study found that a newly developed injectable hydrogel combined with human umbilical cord-mesenchymal stem cells significantly accelerated wound healing and reduced inflammation in full-thickness cutaneous wounds.

research Human Umbilical Cord Blood Mesenchymal Stem Cells Engineered to Overexpress Growth Factors Accelerate Outcomes in Hair Growth

21 citations , January 2018 in “The Korean Journal of Physiology and Pharmacology”

This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations , March 2012 in “Development”

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.