Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2-ARE Pathway in C57BL/6J Mice

    April 2026 in “ Journal of Cosmetic Dermatology ”
    Jingbo Cui, Linxia Duan, Hui Qu … Huihua Zhang
    Studysummary This study found that exosomes derived from human umbilical cord mesenchymal stem cells helped preserve melanocyte function and mitigate stress-induced hair depigmentation in mice by activating the Nrf2-ARE antioxidant pathway under acute neurogenic oxidative stress.
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    Research cited in this study 13

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    2. The Emerging Role of Exosomes in the Treatment of Hair Loss International Journal of Dermatology · 2024
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    4. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway Stem Cells International · 2023
    5. Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF Journal of Cosmetic Dermatology · 2023
    6. Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities Journal of cosmetic dermatology · 2022
    7. Biomarker of Oxidative Stress in Premature Hair Graying at Young Age Open Access Macedonian Journal of Medical Sciences · 2021
    8. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    9. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    10. Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond? BioEssays · 2017
    11. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    12. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    13. Epidemiological and Investigative Study of Premature Graying of Hair in Higher Secondary and Pre-University School Children International Journal of Trichology · 2013