Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update

    January 2025 in “ Journal of Cosmetic Dermatology ”
    Milaan Shah, Victoria Dukharan, Luke Broughton, Carol Stegura, Nina Schur, Luna Samman, Todd Schlesinger
    Image of study
    TLDR Exosomes may help with hair growth and scar healing, but more research is needed.
    Exosomes, small extracellular vesicles, show promise in aesthetic dermatology for conditions like hair loss and scar remodeling. They promote hair growth by activating pathways such as Wnt/β-catenin, with small-scale studies involving 39 and 20 patients reporting increased hair density and thickness. Exosomes from dermal papillae and adipose-derived stem cells have been effective in preclinical models. They also aid scar healing by modulating immune responses and fibroblast activity. Exosomes from adipose-derived and mesenchymal stem cells may inhibit keloid and hypertrophic scar formation and reduce hyperpigmentation. While initial results are promising, larger clinical trials are needed to confirm efficacy, establish treatment protocols, and address standardization and regulatory challenges. The safety profile is initially strong, but further research is necessary.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 156 results

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 3 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community How does low level laser therapy?

      in Chat  5 upvotes 3 months ago
      Low-level laser therapy (LLLT) is debated for hair regrowth, with some users suggesting it should be combined with treatments like minoxidil and finasteride for effectiveness. Many users express skepticism about LLLT's efficacy and cost, emphasizing the need for the correct wavelength and quality devices.

      community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.

      in Research/Science  210 upvotes 1 month ago
      PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.

    Similar Research

    5 / 699 results