Biomarker of Oxidative Stress in Premature Hair Graying at Young Age

May 2021 in “ Open Access Macedonian Journal of Medical Sciences ”

Dwi Rita Anggraini, Lita Feriyawati, Mega Sari Sitorus, Milahayati Daulay

premature hair graying oxidative stress malondialdehyde superoxide dismutase catalase glutathione peroxidase enzyme-linked immunosorbent assay antioxidant supplementation PHG MDA SOD GPx ELISA

Studysummary This study found that individuals with premature hair graying had significantly lower levels of antioxidants compared to controls, but the severity of graying did not significantly correlate with oxidative stress levels. Our plain-language summary of this paper — not a Tressless recommendation.

The study aimed to evaluate oxidative stress markers in individuals with premature hair graying (PHG) and their association with the severity of graying. It involved 40 male participants under 25 years old, comparing those with PHG to healthy controls. The researchers measured serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) using enzyme-linked immunosorbent assay. The results showed that individuals with PHG had higher serum MDA levels, although not significantly so (p > 0.05), and significantly lower levels of antioxidant enzymes SOD, catalase, and GPx (p < 0.001, p = 0.017, and p < 0.001, respectively) compared to controls. There was no significant correlation between oxidative stress and the severity of graying (p > 0.05), but a significant association was found between the onset and severity of graying (p < 0.001). The study concluded that individuals with PHG have an imbalance between pro-oxidants and antioxidants, suggesting that antioxidant supplementation might be beneficial for PHG.

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