Exogenous Alpha-Ketoglutaric Acid Alleviates Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway

April 2025 in “ Antioxidants ”

Xiaosong Wang, Shu Li, Jiali Chen, Lei Liu, Fuchang Li

alpha-ketoglutarate AKG Dermal Papilla Cells hydrogen peroxide H2O2 reactive oxygen species ROS mitochondrial function apoptosis Bcl-2/Bax ratio antioxidant levels ERK/Nrf2 signaling pathway Nrf2 activity oxidative stress α-ketoglutarate DPCs

Studysummary This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explores the protective effects of alpha-ketoglutaric acid (AKG) on rabbit dermal papilla cells (DPCs) under oxidative stress caused by hydrogen peroxide (H2O2). AKG was shown to significantly enhance cell viability, reduce reactive oxygen species (ROS) levels, and maintain mitochondrial membrane potential. It also modulated apoptosis-related proteins, increased antioxidant enzyme activity, and reduced inflammation, primarily through the ERK/Nrf2 signaling pathway. The study involved a sample size of 3 for most assays, with 12 samples for cell viability tests. These findings suggest AKG's potential as a therapeutic agent for oxidative stress-related damage in hair follicle cells.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants

41 citations , June 2024 in “Journal of Cellular and Molecular Medicine”

This study reviews how oxidative stress affects hair follicle development and hair growth, discusses antioxidant-based treatments for hair loss, and evaluates natural antioxidant products that promote hair growth, emphasizing the need for further research due to existing limitations.

Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

research Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

January 2024 in “GeroScience”

This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.

Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

research Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

1 citations , December 2022 in “Pharmaceuticals”

This study found that a sub-fraction of Noni fruit, FEA-3, showed hair growth-promoting effects in a rabbit model of androgenic alopecia, similar to Minoxidil.

Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

research Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

46 citations , March 2019 in “Journal of Pineal Research”

The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.

research Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction

35 citations , January 2017 in “Journal of Dermatological Science”

This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.