Exogenous Alpha-Ketoglutaric Acid Alleviates Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway

    April 2025 in “ Antioxidants ”
    Xiaosong Wang, Shu Li, Jiali Chen, Lei Liu, Fuchang Li
    The study investigates the protective effects of α-ketoglutarate (AKG) against oxidative damage in rabbit Dermal Papilla Cells (DPCs) caused by hydrogen peroxide (H2O2). AKG was found to reduce reactive oxygen species (ROS) production, restore mitochondrial function, and prevent apoptosis by modulating the Bcl-2/Bax ratio and enhancing antioxidant levels. The research highlights the role of the ERK/Nrf2 signaling pathway, where AKG enhances Nrf2 activity to protect cells. Inhibition of ERK negated these protective effects, leading to increased ROS and cell death. The findings suggest that AKG has significant therapeutic potential for oxidative stress-related conditions.
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