Decorin-Mediated Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Growth and Development Through miR-129-2-3p/SMAD3/TGF-β Axis

    Jiali Li, Bohao Zhao, Yongqi Yu, Zhiyuan Bao, Feiyang Zheng, Jiawei Cai, Yang Chen, Xinsheng Wu
    TLDR Decorin helps hair growth by influencing specific cell signals.
    The study investigates the role of decorin (DCN) in promoting hair follicle (HF) growth through dermal papilla cell-derived exosomes (DPC-Exos) and the miR-129-2-3p/SMAD3/TGF-β axis. DCN treatment enhances dermal papilla cell (DPC) proliferation, which is crucial for HF cycling and regrowth. The research identifies 442 differentially expressed exosomal miRNAs, focusing on miR-129-2-3p, which suppresses genes associated with HF growth, promotes HF stem cell proliferation, and reduces apoptosis. The study highlights the potential of DCN-mediated DPC-Exos in developing new strategies for diagnosing and treating hair disorders and improving wool production.
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