Placenta Extract-Loaded Novasome Significantly Improved Hair Growth in a Rat In Vivo Model

May 2023 in “ International Journal of Applied Pharmaceutics ”

Ajeng illastria Rosalina, Iskandarsyah Iskandarsyah, Erny Sagita

bovine placenta extract novasome vesicle hair growth PE-loaded novasome minoxidil liposome entrapment efficiency ultra-deformable properties stability rat in vivo model placenta extract novasome Rogaine

TLDR Placenta extract in novasomes improved rat hair growth better than minoxidil and placenta extract in liposomes.

The research aimed to improve the hair growth effects of bovine placenta extract (PE) by incorporating it into a novasome vesicle. The optimal PE-loaded novasome had a particle size of 155.0 nm, polydispersity index of 0.139, zeta potential of -63.73, and an entrapment efficiency of 79.60%. The novasome demonstrated ultra-deformable properties and maintained stability for 90 days at 4 °C. A rat study showed that the PE-loaded novasome was more effective in promoting hair growth than both PE-loaded liposome and a 2% minoxidil solution. The study concluded that novasome is a promising carrier for large molecules like PE, and PE-loaded in novasome showed superior hair growth effects than minoxidil and PE-loaded liposomes.

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