Placenta Extract-Loaded Novasome Significantly Improved Hair Growth in a Rat In Vivo Model

May 2023 in “ International Journal of Applied Pharmaceutics ”

Ajeng illastria Rosalina, Iskandarsyah Iskandarsyah, Erny Sagita

bovine placenta extract novasome vesicle hair growth PE-loaded novasome minoxidil liposome entrapment efficiency ultra-deformable properties stability rat in vivo model placenta extract novasome Rogaine

TLDR Placenta extract in novasomes improved rat hair growth better than minoxidil and placenta extract in liposomes.

The research aimed to improve the hair growth effects of bovine placenta extract (PE) by incorporating it into a novasome vesicle. The optimal PE-loaded novasome had a particle size of 155.0 nm, polydispersity index of 0.139, zeta potential of -63.73, and an entrapment efficiency of 79.60%. The novasome demonstrated ultra-deformable properties and maintained stability for 90 days at 4 °C. A rat study showed that the PE-loaded novasome was more effective in promoting hair growth than both PE-loaded liposome and a 2% minoxidil solution. The study concluded that novasome is a promising carrier for large molecules like PE, and PE-loaded in novasome showed superior hair growth effects than minoxidil and PE-loaded liposomes.

View this study on journals.innovareacademics.in →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Hair Growth-Promotion Effects at the Cellular Level and Antioxidant Activity of the Plant-Based Extract Phyllotex

7 citations, August 2021 in “Heliyon”

Phyllotex™ extract was found to significantly promote hair growth and protect against hair loss.

research Hair Growth Promoting Effect of Bioactive Extract from Deer Antler Velvet-Loaded Niosomes and Microspicules Serum

14 citations, February 2021 in “International Journal of Pharmaceutics”

Deer antler velvet serum helps hair grow and is safe for skin.

Evaluation of the Efficacy and Safety of Cow Placenta Extract Lotion Versus Minoxidil 2% in the Treatment of Female Pattern Androgenetic Alopecia

research Evaluation of the Efficacy and Safety of Cow Placenta Extract Lotion Versus Minoxidil 2% in the Treatment of Female Pattern Androgenetic Alopecia

4 citations, May 2020 in “International Journal of Women's Dermatology”

Cow placenta lotion works like minoxidil 2% for female hair loss, with fewer side effects.

research Known and Unknown Features of Hair Cuticle Structure: A Brief Review

27 citations, May 2019 in “Cosmetics”

The hair cuticle is made of tough proteins that protect the hair, but more research is needed to fully understand its structure.

research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

260 citations, January 2019 in “Pharmaceutics”

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride

50 citations, March 2017 in “PeerJ”

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

research Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.

1 citations, January 2017 in “Elsevier eBooks”

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research Hair Restoration Surgery: Challenges and Solutions

31 citations, July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Hair restoration surgery effectively treats hair loss with natural-looking results, using techniques like stem cells and platelet-rich plasma.

research A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In Vitro and In Vivo Assessments

1 citations, January 2015 in “Journal of clinical and investigative dermatology”

IGF-1 from human placenta helps hair grow.

research Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo

53 citations, March 2014 in “Growth Hormone & IGF Research”

IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.

research Effect of Citrullus Colocynthis on Hair Growth in Albino Rats

18 citations, January 2007 in “Pharmaceutical Biology”

Citrullus colocynthis extract is effective for hair growth, comparable to minoxidil.

Related Research

6 / 6 results

Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.

research Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes

8 citations, April 2019 in “Dermatologic Therapy”

Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.

research The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years

5 citations, January 2018 in “Italian journal of dermatology and venereology”

Minoxidil effectively stimulates hair growth in androgenetic alopecia.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

research Androgenetic Alopecia: Treatment Results with Topical Minoxidil

39 citations, March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.

research Topical Minoxidil Therapy and Hair Regrowth

20 citations, February 1985 in “Archives of Dermatology”

Minoxidil helps hair regrowth, especially with more indeterminate hairs.