A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In Vitro and In Vivo Assessments

January 2015 in “ Journal of clinical and investigative dermatology ”

Yeon A No, Tae‐Rin Kwon, Hye Yun Park, Hyun Jung Han, Hyung-Jin Jeong, Youngsook Huh, Joon Kim, Beom Kim

IGF-1 human placenta hydrolysate HPH GSK-3β beta-catenin dermal papilla cells hair follicles C57BL6/J mice insulin-like growth factor 1 placenta extract

TLDR IGF-1 from human placenta helps hair grow.

The study investigated the role of IGF-1, a component of human placenta hydrolysate (HPH), in promoting hair growth. Researchers tested IGF-1 and an amino acid mixture on human dermal papilla cells and observed their effects on GSK-3β and beta-catenin signaling pathways. Additionally, they examined the impact of IGF-1 on hair follicle development in C57BL6/J mice. Results showed that IGF-1 enhanced hair growth signals, increasing both the number and size of hair follicles in treated groups, suggesting that IGF-1 could be a key component of HPH responsible for its hair growth-promoting effects.

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