A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In Vitro and In Vivo Assessments

January 2015 in “ Journal of clinical and investigative dermatology ”

Yeon A No, Tae‐Rin Kwon, Hye Yun Park, Hyun Jung Han, Hyung-Jin Jeong, Youngsook Huh, Joon Kim, Beom Kim

IGF-1 human placenta hydrolysate HPH GSK-3β beta-catenin dermal papilla cells hair follicles C57BL6/J mice insulin-like growth factor 1 placenta extract

TLDR IGF-1 from human placenta helps hair grow.

The study investigated the role of IGF-1, a component of human placenta hydrolysate (HPH), in promoting hair growth. Researchers tested IGF-1 and an amino acid mixture on human dermal papilla cells and observed their effects on GSK-3β and beta-catenin signaling pathways. Additionally, they examined the impact of IGF-1 on hair follicle development in C57BL6/J mice. Results showed that IGF-1 enhanced hair growth signals, increasing both the number and size of hair follicles in treated groups, suggesting that IGF-1 could be a key component of HPH responsible for its hair growth-promoting effects.

View this study on avensonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 53 results

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 3 months ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community Oral minoxidil is not good for your health, let’s use research chemicals bought from AliExpress

in Satire 551 upvotes 2 years ago

. This conversation discussed the efficacy of Minoxidil and Finasteride as treatments for hair loss, with a focus on the potential side effects of taking Oral Minoxidil. Some users shared their experiences with both treatments and there was debate over whether they were safe or not.

community Sandalore: a scientific homemade approch

20 upvotes 6 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community Is there any point to microneedling if you're on oral minoxidil?

in Microneedling 45 upvotes 1 year ago

Microneedling's effectiveness for hair regrowth is debated, with mixed results from studies. Some believe it helps with blood flow and scalp health, while others see it as largely ineffective.

community Signs of life. Ru, topical fin/min, mk677, micro needling

in Progress Pictures 192 upvotes 3 years ago

The conversation discusses using RU58841, topical finasteride/minoxidil, MK677, and microneedling as treatments for hair loss. MK677 is mentioned as a growth hormone that improves hair health and recovery from microneedling.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Similar Research

5 / 1000+ results

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations, August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Placental Extracts, Proteins, and Hydrolyzed Proteins as Active Ingredients in Cosmetic Preparations for Hair Loss: A Systematic Review of Available Clinical Evidence

research Placental Extracts, Proteins, and Hydrolyzed Proteins as Active Ingredients in Cosmetic Preparations for Hair Loss: A Systematic Review of Available Clinical Evidence

November 2024 in “Applied Sciences”

Placenta products might help with hair loss, but more research is needed.

Placenta Extract-Loaded Novasome Significantly Improved Hair Growth in a Rat In Vivo Model