Hypoxia-Derived Mesenchymal Stem Cell Exosomes Downregulate CXCL12 and Upregulate IL-10 Expression in a Murine Model of Androgenic Alopecia

    March 2026 in “ Molecular and Cellular Biomedical Sciences ”
    Denawati Denawati, Eko Setiawan, Sri Priyantini
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    TLDR EH-MSCs may help treat hair loss by reducing inflammation.
    This study investigated the effects of exosomes derived from hypoxia-conditioned mesenchymal stem cells (EH-MSCs) on inflammatory mediators in a DHT-induced androgenic alopecia (AGA) mouse model. Male C57BL/6 mice were divided into five groups, including a healthy control and various treatment groups. The results showed that DHT induction increased CXCL12 expression and decreased IL-10 levels. EH-MSC treatment dose-dependently downregulated CXCL12 and upregulated IL-10 expression, demonstrating greater immunomodulatory effects than minoxidil. The findings suggest that EH-MSCs could serve as a potential immunoregenerative therapeutic strategy for AGA by modulating key inflammatory biomarkers.
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