Human Hair Follicle-Derived Mesenchymal Stem Cells Promote Tendon Repair in a Rabbit Achilles Tendinopathy Model

April 2023 in “ Chinese Medical Journal ”

Yingyu Ma, Zhiwei Lin, Xiaoyi Chen, Xin Zhao, Yi Sun, Ji Wang, Xiaozhou Mou, Hai Zou, Jinyang Chen

human hair follicle-derived mesenchymal stem cells hHF-MSCs collagen fiber prokaryotic cell tendon repair Achilles tendinopathy regenerative treatment stem cells collagen

Studysummary In this study, human hair follicle-derived mesenchymal stem cells promoted Achilles tendon repair in rabbits by upregulating collagen types I and III, suggesting potential as a treatment for tendinopathy.

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The study explored the effects of human hair follicle-derived mesenchymal stem cells (hHF-MSCs) on Achilles tendinopathy repair in rabbits. Results showed that hHF-MSCs significantly improved tendon repair, with better collagen fiber arrangement, increased prokaryotic cell numbers, and higher maximum tensile strength compared to untreated tendons. Molecular analyses revealed elevated expression of repair-related genes and proteins. These findings suggest that hHF-MSCs have potential as a regenerative treatment for tendon injuries.

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AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

research AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

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This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.

Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

research Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

70 citations , February 2021 in “International Journal of Molecular Sciences”

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Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

This review evaluates various kits for isolating platelet-rich plasma using established processing standards and finds they enable compliance with consensus quality criteria; ongoing research is needed to refine these procedures for improved consistency and safety.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations , June 2017 in “Stem cell investigation”

This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.

research The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine

30 citations , March 2017 in “ACS biomaterials science & engineering”

This review discusses the structure and regenerative potential of hair follicles, highlighting their role in wound healing, stem cell populations, and keratin-based biomaterials, but it reports no new clinical results.