Mechanotransduction Unifies Healthy Non-Diabetic Wound Healing Over Time by Promoting a Cd14+/C1qa+ Fibroblast Subpopulation

April 2026 in “ Journal of Investigative Dermatology ”

Katharina S. Berryman, Abdelrahman M. Alsharif, Mansi Singh, Filiberto Quintero, Amelia B. Knochel, Maria Gracia Mora Pinos, Dharshan Sivaraj, Lulejeta Latifi, Fidel Jr. Saenz, Pedro Mora Pinos, Andrew C. Hostler, Javier Raya González, Ben Litmanovich, Sultana Mojadidi, Jonathan P. Yasmeh, Hudson Kussie, Maisam S. Jafri, Autumn Lester, William W. Hahn, Maia Granoski, Geoffrey C. Gurtner, Kellen Chen

mechanotransduction fibroblast Cd14+/C1qa+ fibroblasts angiogenic fibroblasts FAK pathway MAPK pathway fibrotic fibroblasts WNT pathway diabetic wound healing non-diabetic wound healing

Studysummary This research observed that diabetes impairs wound healing in mice by disrupting key mechanotransduction pathways in fibroblasts, which are crucial for the healing process. The study also suggests transcriptomic changes could inform future diabetic wound repair therapies.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Targeting Wnt/β-Catenin Signaling and Its Interplay with TGF-β and Notch Signaling Pathways for the Treatment of Chronic Wounds

74 citations , April 2024 in “Cell Communication and Signaling”

This review highlights the role of the Wnt/β-catenin signaling pathway in wound healing, particularly in diabetic ulcers, discussing its interactions with other pathways and potential therapeutic strategies targeting this pathway, such as photobiomodulation.

research Fibroblast Heterogeneity in Healthy and Wounded Skin

4 citations , June 2022 in “Cold Spring Harbor Perspectives in Biology”

This review discusses the heterogeneity of dermal fibroblasts in healthy mouse and human skin and reports no clinical results; the authors highlight potential insights into physiological and pathological wound healing.

research Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds

301 citations , February 2019 in “Nature Communications”

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.