Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration After Extensive Liver Resection in Rats
February 2018
in “
Scientific Reports
”
TLDR Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.
In 2018, a study was conducted on 60 rats to investigate the impact of mobilizing endogenous bone marrow stem cells on liver regeneration after extensive liver resection. The rats were treated with a drug called AMD3100, which resulted in a higher survival rate of 83.3% compared to the control group's 50%. The AMD3100-treated rats also showed enhanced liver regeneration, indicated by increased liver weight and improved liver function tests. The study concluded that pharmacological mobilization of endogenous bone marrow stem cells can enhance liver regeneration and improve liver function after extensive hepatectomy.
