Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

March 2014 in “ Journal of Investigative Dermatology ”

Qi Lin, Russell Wesson, Hiromichi Maeda, Yongchun Wang, Zhu Cui, Jun O. Liu, Andrew M. Cameron, Bin Gao, Robert A. Montgomery, G. M. Williams, Zhaoli Sun

AMD3100 Tacrolimus hair follicle neogenesis CD133+CD31+ stem/progenitor cells SDF-1 stem cell mobilization wound healing skin regeneration Plerixafor Protopic

Studysummary This study demonstrated that combining AMD3100 with low-dose tacrolimus in a stem cell mobilization approach significantly reduced wound healing time and improved scar and hair follicle regeneration in full-thickness skin wounds. Our plain-language summary of this paper — not a Tressless recommendation.

Nine years ago, a study investigated the combined effects of two drugs, AMD3100 and Tacrolimus, on skin regeneration after full-thickness excision. The results showed that this combination significantly improved wound closure rate and stimulated hair follicle neogenesis, reducing scarring. The treatment led to an accumulation of CD133+CD31+ stem/progenitor cells in the wounded skin, suggesting these cells play a crucial role in the healing process. The study also found that the SDF-1 mediated stem/progenitor cell mobilization was critical for the improved wound healing. The study concluded that pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision.

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