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GlossaryPlerixafor (AMD3100)

medication mobilizes stem cells from bone marrow to bloodstream

Plerixafor, also known as AMD3100, is a medication used to mobilize hematopoietic stem cells from the bone marrow into the bloodstream, making it easier to collect them for transplantation. It works by inhibiting the CXCR4 receptor, which normally helps keep these stem cells in the bone marrow.

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Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

research Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

49 citations, March 2014 in “Journal of Investigative Dermatology”

Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.

Pharmacological Mobilization and Recruitment of Bone Marrow Stem Cells Accelerates Diabetic Wound Healing in Rats with Diabetic Complications

research Pharmacological Mobilization and Recruitment of Bone Marrow Stem Cells Accelerates Diabetic Wound Healing in Rats with Diabetic Complications

June 2019 in “Diabetes”

Using a combination of AMD3100 and FK506 can speed up and improve wound healing in diabetic rats.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations, December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats

research Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats

16 citations, January 2020 in “Diabetes”

A new therapy sped up wound healing and reduced scarring in diabetic rats.

Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration After Extensive Liver Resection in Rats

research Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration After Extensive Liver Resection in Rats

12 citations, February 2018 in “Scientific Reports”

Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.

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