TLDR Using a specific binding agent and low doses of FK506 can stimulate stem cells, speeding up skin healing by 25% and improving skin quality in rats and mice.
The 2015 study "Skin Wound Healing" explored the role of bone marrow stem cells in wound healing and skin regeneration. The researchers found that the combination of the C-X-C chemokine receptor type 4 (CXCR4) binding agent AMD-3100 and subimmunosuppressive doses of FK506 could stimulate the release of essential stem cells from the bone marrow, aiding in graft survival and creating a chimeric graft. This method, when applied to excisional wounds in rats and mice, resulted in 25% faster skin healing, with a well-organized and thinner dermis, and the presence of skin appendages. The study also identified the presence of multiple growth factors and angiogenic cytokines in the wounds. Stem cells bearing the CD133 marker were found to be the main contributors to the formation of new blood vessels, epidermis, and hair follicles. The same positive outcomes were observed in burn wounds.
49 citations,
March 2014 in “Journal of Investigative Dermatology” Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.
78 citations,
June 2013 in “Science” Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.
237 citations,
June 2013 in “Nature Medicine” A protein from certain immune cells is key for new hair growth after skin injury in mice.
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October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.
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December 2013 in “Stem Cells” Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.
163 citations,
March 2012 in “BMC biology” Stem cell niches support, regulate, and coordinate stem cell functions.
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January 2024 in “Signal transduction and targeted therapy” Lymphatic vessels are essential for health and can be targeted to treat various diseases.
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1 citations,
January 2021 CD4+ skin cells may be precursors to basal cell carcinoma.
271 citations,
May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
