TLDR The circadian clock influences the behavior and regeneration of stem cells in the body.
The document reviewed the role of the circadian timing system, a network that regulates 24-hour rhythms in behavioral and physiological processes, in stem cell homeostasis. It highlighted that various stem cell-dependent processes, including migration of hematopoietic progenitor cells, the hair follicle cycle, bone remodeling, regenerative myogenesis, and neurogenesis, exhibit rhythmic oscillations influenced by the circadian clock. The review focused on the characteristics of the circadian clock in embryonic stem cells and its alterations during differentiation. Additionally, it explored the impact of the circadian clock on the function of adult stem cells in different body tissues, particularly emphasizing its contribution to adult neurogenesis in the brain.
Cited in this study
6 / 6 results
127 citations
,
January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
116 citations
,
May 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.
221 citations
,
July 2012 in “Proceedings of the National Academy of Sciences of the United States of America” BMAL1 controls skin cell growth and UV damage risk, peaking at night.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
1039 citations
,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
375 citations
,
February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
