Stem Cells and the Circadian Clock

September 2017 in “ Developmental biology ”

Meltem Weger, Nicolas Diotel, Anne Claire Dorsemans, Thomas Dickmeis, Benjamin D. Weger

hair follicle cycle circadian clock stem cell homeostasis hematopoietic progenitor cells

TLDR The circadian clock influences the behavior and regeneration of stem cells in the body.

The document reviewed the role of the circadian timing system, a network that regulates 24-hour rhythms in behavioral and physiological processes, in stem cell homeostasis. It highlighted that various stem cell-dependent processes, including migration of hematopoietic progenitor cells, the hair follicle cycle, bone remodeling, regenerative myogenesis, and neurogenesis, exhibit rhythmic oscillations influenced by the circadian clock. The review focused on the characteristics of the circadian clock in embryonic stem cells and its alterations during differentiation. Additionally, it explored the impact of the circadian clock on the function of adult stem cells in different body tissues, particularly emphasizing its contribution to adult neurogenesis in the brain.

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Research cited in this study

7 / 7 results

research The Circadian Clock in Skin

127 citations, January 2015 in “Journal of Biological Rhythms”

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

research Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling

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Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

research Brain And Muscle Arnt-Like Protein-1 (BMAL1) Controls Circadian Cell Proliferation And Susceptibility To UVB-Induced DNA Damage In The Epidermis

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BMAL1 controls skin cell growth and UV damage risk, peaking at night.

research Development and Homeostasis of the Skin Epidermis

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The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

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The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

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Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research The Hair Cycle

375 citations, February 2006 in “Journal of Cell Science”

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research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

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research PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

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Stem Cells and the Circadian Clock

Research cited in this study

research The Circadian Clock in Skin

research Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling

research Brain And Muscle Arnt-Like Protein-1 (BMAL1) Controls Circadian Cell Proliferation And Susceptibility To UVB-Induced DNA Damage In The Epidermis

research Development and Homeostasis of the Skin Epidermis

research The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

research The Hair Cycle

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