Stem Cells and the Circadian Clock

    September 2017 in “ Developmental biology ”
    Meltem Weger, Nicolas Diotel, Anne Claire Dorsemans, Thomas Dickmeis, Benjamin D. Weger
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    TLDR The circadian clock influences the behavior and regeneration of stem cells in the body.
    The document reviewed the role of the circadian timing system, a network that regulates 24-hour rhythms in behavioral and physiological processes, in stem cell homeostasis. It highlighted that various stem cell-dependent processes, including migration of hematopoietic progenitor cells, the hair follicle cycle, bone remodeling, regenerative myogenesis, and neurogenesis, exhibit rhythmic oscillations influenced by the circadian clock. The review focused on the characteristics of the circadian clock in embryonic stem cells and its alterations during differentiation. Additionally, it explored the impact of the circadian clock on the function of adult stem cells in different body tissues, particularly emphasizing its contribution to adult neurogenesis in the brain.
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