Molecular Interactions of New Pregnenedione Derivatives

    January 2003 in “ Chemical and Pharmaceutical Bulletin ”
    Marisa Cabeza, Elena Ramı́rez, Eugenio Flores, Norma Valencia, Mauricio Sánchez, Ivonne Heuze, Marisa Cabeza
    Image of study
    TLDR The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
    The study evaluated the in vitro inhibitory activity of five new progesterone derivatives on the 5α-reductase enzyme and their antagonistic effects on the androgen receptor. The compounds showed varying IC50 values for 5α-reductase inhibition, with compound 3 being the most potent (19 nM). The Ki values indicated that compound 4 had the highest affinity for the androgen receptor, followed by compound 5, dihydrotestosterone, compound 2, compound 3, and compound 1. Overall, all five synthesized compounds were effective 5α-reductase inhibitors and exhibited affinity for the androgen receptor in the hamster prostate.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 115 results

      community Nandrolone Replacement Therapy

      in Treatment  41 upvotes 1 year ago
      A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 9 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community Just had this wild thought come into my head.

      in Satire  403 upvotes 9 months ago
      The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.

      community Progressive insomnia (treatment-resistant) due to Finasteride

      in Finasteride/Dutasteride  7 upvotes 2 years ago
      A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

      community Started Finasteride almost three months ago and I'm upset

      in Update  153 upvotes 9 months ago
      A user started taking finasteride three months ago to treat hair loss and unexpectedly cleared their acne, which they had been struggling with since age 12. The conversation includes others sharing their experiences with finasteride, its effects on acne and hair loss, and mentions a related treatment, clascoterone, for acne and hair loss.

      community Ultimate Hairloss Flowchart (for beginners)

      in Treatment  247 upvotes 1 year ago
      The conversation discusses a hair loss flowchart for beginners, with mixed opinions on its effectiveness. Treatments mentioned include minoxidil, finasteride, dutasteride, microneedling, and vitamins.

    Similar Research

    6 / 1000+ results