Image

    Relative Binding Affinity of Novel Steroids to Androgen Receptors in Hamster Prostate

    January 2005 in “ Journal of Enzyme Inhibition and Medicinal Chemistry ”
    Marisa Cabeza, Ivonne Heuze, María del Carmen Sánchez … George Chaves Jimenez
    Studysummary This study found that certain steroidal compounds, especially 10a–10c, demonstrated strong antiandrogenic activity by binding to the androgen receptor and reducing prostate weight in a hamster model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on tandfonline.com →
    Discuss this study in the Community →

    Research cited in this study 6

    1. New Aromatic Esters of Progesterone as Antiandrogens Journal of Enzyme Inhibition and Medicinal Chemistry · 2004
    2. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003
    3. Molecular Interactions of New Pregnenedione Derivatives Chemical and Pharmaceutical Bulletin · 2003
    4. Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors Chemical & Pharmaceutical Bulletin · 2001
    5. Androgenic and Anti-Androgenic Effects of Progesterone Derivatives with Different Halogens as Substituents at the C-6 Position Steroids · 1999
    6. Combination of an Antiandrogen and a 5α-Reductase Inhibitor: A Further Step Towards Total Androgen Blockade? Endocrinology · 1991