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    Research 10 of 1000+

    1. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    2. Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis British Journal of Dermatology · 1997 · 12 citations
    3. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men. The Journal of Clinical Endocrinology and Metabolism · 1996 · 6 citations
    4. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    5. Analysis of genetic polymorphisms of steroid 5α-reductase type 1 and 2 genes in Korean men with androgenetic alopecia Journal of Dermatological Science · 2003 · 15 citations
    6. Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2 Steroids · 2017 · 8 citations
    7. Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics Scientific Reports · 2022
    8. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    9. The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals Brazilian Journal of Medical and Biological Research · 2003 · 17 citations
    10. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
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    Community 10 of 84

    1. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    2. How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR? Reddit · 26 Jun 2024
    3. 5ar Type I in the frontal hair follicles - Dutasteride Reddit · 30 Apr 2024
    4. Was scared to try fin and jumped straight to 2.5mg Dut? Reddit · 12 Sept 2026
    5. Thoughts on this Article: Post-Finasteride and Neurological Effects Reddit · 16 Mar 2024
    6. The truth about Dutasteride (w/ sources) Reddit · 24 Jan 2023
    7. Whats up with all the dutasteride destroying hair posts Reddit · 12 May 2023
    8. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
    9. My story (22m, fin, min, niz, RU, dut –> part frontal hair system) Reddit · 6 May 2023
    10. Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others. Reddit · 18 May 2023
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    Learn 3 of 6

    1. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    2. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    3. Neem Oil Oil from the neem tree, used in traditional remedies
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