Melasma, A Photoaging Disorder

    December 2017 in “ Pigment cell & melanoma research ”
    Thierry Passeron, Mauro Picardo
    TLDR Melasma is now considered a skin aging disorder caused by sun exposure in people with a genetic tendency, which impacts treatment and prevention approaches.
    Melasma was identified as a complex photoaging disorder influenced by factors beyond female hormones, affecting both melanocytes and the dermis. UV radiation, including visible light, exacerbated the condition, highlighting the need for broad-spectrum photoprotection. Traditional treatments often failed to prevent relapses, but emerging therapies targeting the WNT pathway, vascular components, and using agents like tranexamic acid showed promise. A holistic approach recognizing melasma as a photoaging disorder was recommended for effective treatment and prevention, with new therapeutic targets including depigmenting agents, photoprotection, and treatments targeting various cellular components.
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