Efficacy and Safety of an Oral Nutritional Supplement Containing Pinus Pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

    March 2019 in “ Cosmetics ”
    Sonia Aladrén, Aurora Garre, Palmira Valderas-Martínez, Jaime Piquero-Casals, Corinne Granger
    TLDR The oral supplement with Pinus pinaster and Grape seed extract, used with sunscreen, effectively and safely improved mild-to-moderate facial melasma.
    The study evaluated the efficacy and safety of an oral nutritional supplement containing Pinus pinaster bark extract and grape seed extract, combined with a high SPF sunscreen, in treating mild-to-moderate melasma in 30 women. Over 84 days, significant reductions in melasma severity were observed, with mean variation percentages of -18.2% at day 28, -33.7% at day 56, and -41.4% at day 84. Both physician and patient assessments indicated increased improvement over time, with 93.3% of physicians and 96.7% of patients reporting improvement at day 84. The treatment was well-tolerated, with no significant adverse effects reported. The study concluded that the combination treatment was effective and safe for managing melasma.
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